Prescription: Murder The perfect crime had one flaw. In Columbo's first outing, a psychiatrist uses a patient he is having an affair with to help him kill his wife, but his perfect alibi may come apart at the hands of a seemingly befuddled LAPD lieutenant. Details Casts Galleries Posters Title Prescription: Murder Release Date 1968-02-20 Runtime 01 Hours 40 Minutes Genres Crime Mystery TV Movie Drama Production Companies Universal Television Production Countries United States of America Peter Falk... Columbo... Gene Barry... Dr. Ray Flemming... Katherine Justice... Joan Hudson... William Windom... Burt Gordon... Nina Foch... Carol Flemming... Virginia Gregg... Miss Petrie... Andrea King... Cynthia Gordon... Susanne Benton... The Blonde... Ena Hartman... Nurse... Sherry Boucher... Air Hostess... Anthony James... Tommy... Frank Baker... Man in Park (uncredited)... Jim Creech... Policeman in Hospital (un... Ed Haskett... Party Guest (uncredited)... Clark Howat... Doctor (uncredited)... Mark Russell... Policeman (uncredited)... Don Stewart... Airline Ticket Man (uncre... Tom Williams... Laundry Delivery Man (unc... Original Size (1280x720) Original Size (1440x810) Original Size (1440x810) Original Size (500x750) Original Size (808x1212) Original Size (2000x3000) Original Size (2000x3000) Original Size (2000x3000) Original Size (2000x3000)