One True Thing Love What You Have. A career woman reassesses her parents' lives after she is forced to care for her cancer-stricken mother. Details Casts Videos Galleries Posters Title One True Thing Release Date 1998-09-18 Runtime 02 Hours 07 Minutes Genres Drama Romance Production Companies Universal Pictures, Monarch Pictures, Ufland Production Countries United States of America Meryl Streep... Kate Gulden... Renée Zellweger... Ellen Gulden... William Hurt... George Gulden... Tom Everett Scott... Brian Gulden... Lauren Graham... Jules... Nicky Katt... Jordan Belzer... James Eckhouse... District Attorney... Patrick Breen... G.A. Tweedy... Gerrit Graham... Oliver Most... David Byron... Senator Sullivan... Stephen Peabody... Harold... Lizbeth MacKay... Dr. Cohen... Mary Catherine Wright... Clarice... Sloane Shelton... Evelyn Best... Michele Shay... June... Bobo Lewis... Muriel... Marylouise Burke... Louisa... Marcia Jean Kurtz... Marcia... Diana Canova... Diana... John Deyle... Santa / Mayor... Hallee Hirsh... Ellen - Age 8... Jeffrey Scaperrotta... Brian - Age 4... Todd Cerveris... Casey... Anna Carolina Alvim... Nurse Teresa... Julie Janney... Hospital Nurse... Susan Stout... Tweedy's Secretary... Greg Hedtke... Magazine Executive... Christian James... Magazine Executive... Lauren Toub... Halloween Girl... Ashley Remy... Halloween Girl... Saul Williams... Graduate Student... Julianne Nicholson... College Student... Amber Kain... College Student... Yolande Bavan... Nari... Benjamin Andrews... Party Kid... Kathryn Walsh... Party Kid... One True Thing Official Trailer #1 - Meryl Streep Movie (1998) HD (Trailer) Original Size (1920x1080) Original Size (1000x1500) Original Size (500x750) Original Size (505x750) Original Size (1000x1500) Original Size (1400x2100) Original Size (2000x3000) Original Size (687x1000) Original Size (1515x2175) Original Size (662x993) Original Size (1066x1599)