My Sister Sam My Sister Sam is an American situation comedy series that aired on CBS from October 1986 to April 1988. The series stars Pam Dawber and Rebecca Schaeffer. Details Casts Galleries Posters Season Lists Title My Sister Sam Genres Comedy Family First Air Date 1986-10-06 Last Air Date 1988-04-12 Episode Runtime 00 Hours 24 Minutes Total Season(s) 2 Total Episode(s) on All Seasons 44 Runtime 24 Production Companies Unknown Pam Dawber... Samantha Russell... Rebecca Schaeffer... Patti Russell... Jenny O'Hara... Dixie Randazzo... Joel Brooks... J.D. Lucas... David Naughton... Jack Kincaid... Original Size (1920x1080) Original Size (1000x1500) Original Size (1000x1500) Season 1 22 Episode(s) 1986-10-06 Season 2 22 Episode(s) 1987-10-03